DOXORRUBICINA LIPOSOMAL PEGILADA PDF

Sample records for doxorrubicina liposomal pegilada . By modulating the liposomal membrane, liposomes can become sensitive towards enzymatically- driven. Pages CARTAS CIENTÍFICO-CLÍNICAS. DOI: /S(09) Erupción intertriginosa por doxorrubicina liposomal pegilada. Visits. Year/Month, Html, Pdf, Epub, Total. November, 2, 0, 0, 2. October, 22, 0, 0, September, 4, 0, 0, 4. August, 0, 1, 0, 1. July, 0, 0, 0, 0.

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As amostras seriadas d Directory of Open Access Journals Sweden. Other seven dogs received 5ml of 0.

All animals were evaluated periodically by means of M-mode and two-dimensional echocardiographic exams. The development of an experimental model of myocardiopathy induced by Doxorubicin in rats.

After six months, the animals dosorrubicina subjected to cardiotomy and their hearts were weighted and submitted to transversal cuts, from which fragments for a macro and micro study were obtained.

These fragments were studied considering their external and internal diameters and the thickness of the left ventricle Doxxorrubicina. The histological pieces were analyzed for the presence of fibrosis, cytoplasmic vacuolization, necrosis and size of nucleus variation.

Data obtained was submitted to statistical analysis with Student’s t test. The presence of polymorphonuclear cells was also observed. Doxorubicin was effective in the promotion of macro and microscopic alterations in the cardiac tissue of rats, possibly constituting a model for the experimental study of myocardiopathy. Desenvolver um modelo experimental de miocardiopatia induzida por doxorrubicina em ratos.

Pathophysiologic Trigger in Doxorubicin-induced Dilated Cardiomyopathy. Doxorubicin-induced dilated cardiomyopathy is one of the main adverse effects in the treatment of patients with malignant tumours. Oxidative stress is one of the pathophysiological mechanisms that play a key role in the establishment of the disease caused by this anthracycline-type antibiotic.

Understanding these pathophysiologic mechanisms becomes of vital importance in order to carry out pharmacological and nutritional intervention strategies to help paddling the harmful effects of this antineoplastic. As part of this research we conducted an updating literature review on the subject and provided ideas that can be useful for the scientific community engaged in the treatment of this chronic disease, which aims to improve the life quality of patients suffering from it.

Cytotoxic drugs encapsulated into liposomes were originally designed to increase the anticancer response, while minimizing off-target adverse effects.

The first liposomal chemotherapeutic drug was approved for use in humans more than 20years ago, and the first publication regarding its use This effect seems very heterogeneously distributed in the tumour.

Also, it is potentially not as ubiquitously occurring as once thought, and it may prove important to select patients Liposomes are biodegradable and non-toxic and can elicit both Boronated liposome development and evaluation.

The boronated liposome development and evaluation effort consists of two separate tasks. The lioosomal is the development of new boron compounds and the synthesis of known boron species with BNCT potential. These compounds are then encapsulated within liposomes for the second task, biodistribution testing in tumor-bearing mice, which examines the potential for dkxorrubicina liposomes and their contents to concentrate boron in cancerous tissues.

Liposome based radiosensitizer dixorrubicina therapy. Liposome -encapsulated chemotherapeutics have been used in the treatment of a variety of cancers and are feasible for use as mono-therapeutics as well as for combination therapy in conjunction with other modalities.

Despite widespread use of liposomal drugs in cancer patient care, insufficient drug Propulsion of liposomes using bacterial motors. Here we describe the utilization of flagellated bacteria as actuators to propel spherical liposomes by attaching bacteria to the liposome surface. Bacteria were stably attached to liposomes using a cross-linking antibody.

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The effect of the number of attached bacteria on propulsion speed was experimentally determined. The effects of bacterial propulsion on the bacteria—antibody— liposome complex were stochastic. We demonstrated that liposomal mobility increased when bacteria were attached, and the propulsion speed correlated with the number of bacteria. Biological activity of liposomal vanillin. This article presents a study of vanillin encapsulation inside multilamellar liposomeswith emphasis on the evaluation of antioxidant activity, the hemolytic effect, and the antisickling properties of these products.

Egg phosphatidylcholine-cholesterol and egg phosphatidylcholine-cholesterolO-decylglycerol liposomes were prepared by mechanical dispersion, all with vanillin included. Vesicles were characterized by determination of encapsulation efficiency and vanillin retention capacity. Antioxidant activity was determined by the 2,2-diphenylpicrylhydrazyl DPPH method.

Anaphylaxis to Pegylated Liposomal Doxorubicin: A Case Report

The hemolytic effect of liposomes was also evaluated by spectrophotometry, as well as the antisickling activity by the Huck test using optical microscopy.

Results showed that the lipid composition of liposomes did not significantly affect the encapsulation efficiency.

Stable vesicles pegilxda obtained with a high retention percentage of vanillin. Liposomes exhibited a high capture of the DPPH radical liposokal to free vanillin and 1-O-decylglycerol C10 in solution.

Vesicles caused no significant hemolisys in normal erythrocytes, nor in those coming from patients with sickle cell anemia. Vanillin encapsulated in liposomes retained its antisickling activity, with a greater effect for Ccontaining vesicles. Our results show that vanillin encapsulation in liposomes is a way to enhance the pharmacologic properties of this molecule using a suitable vehicle.

Liposome Technology for Industrial Purposes. Full Text Available Liposomesspherical vesicles consisting of one or more phospholipid bilayers, were first doxorruicina in the mid 60s by Bangham and coworkers.

Since then, liposomes have made their way to the market. Today, numerous lab scale but only a few large-scale techniques are available. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability.

An additional point of view was taken to regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents. Phospholipid liposomes functionalized by protein. Finding new ways to deliver neurotrophic drugs to the brain in newborns is one of the contemporary problems of medicine and pharmaceutical industry.

Modern researches in this field indicate the promising prospects of supramolecular transport systems for targeted drug delivery to the brain which can overcome the blood-brain barrier BBB. Thus, the solution of this problem is actual not only for medicine, but also for society as a whole because it roxorrubicina the health of future generations.

Phospholipid liposomes due to combination of lipo- and hydrophilic properties are considered as the main future objects in medicine for drug delivery through the BBB as well as increasing their bioavailability and toxicity. Liposomes functionalized by various proteins were used as transport systems for ease of liposomes use.

Designing of modification oligosaccharide of liposomes surface is promising in the last decade because it enables the delivery of liposomes to specific receptor of human cells by selecting ligand and it is widely used in pharmacology for the treatment of several diseases.

The purpose of this work is creation of a coarse-grained model of bilayer of phospholipid liposomesfunctionalized by specific to the structural elements of the BBB proteins, as well as prediction of the most favorable orientation and position of the molecules in the generated complex by methods of molecular docking for the formation of the structure.

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Investigation of activity of the ligand molecule to protein receptor of human cells by the methods of molecular dynamics was carried out. Full Text Available Introduction. With the transport links development there is rather important issue respiratory viral infections spread, especially influenza.

Clinical trials

The only method controlling influenza is vaccination. Search and development effective and safe vaccines is important. In assessing the influenza vaccine safety is using a few criteria, including, reactivity, as measured by the frequency of local and systemic adverse negative effects, which due to its introduction, and for lipid content drugs, ability to influence oxidation processes.

At present study phase was determined: Study objects were trivalent seasonal influenza vaccine, “Vaxigrip” Sanofi Pasteur, S. Berne, Switzerland and experimental vaccine samples. Highest immunogenicity vaccines had undergone improvements and modifications using adjuvant systems and acylation influenza proteins. Liposomes 2 — the experimental influenza vaccine with a liposome negative charge and antigenic composition like split vaccines “Vaksihryp”.

Liposomal preparation by supercritical fluids technology Zhong African Journal of Biotechnology Octanol-assisted liposome assembly on chip. Liposomes are versatile supramolecular assemblies widely used in basic and applied sciences. Liposomes as carriers of imaging agents. This review discusses the utilization of liposomes as imaging agents or as vehicles for contrast materials.

The initial approach was the use of radiolabeled liposomes for scintigraphy. To this end liposomes were either labeled in the lipid membrane or aqueous radiotracers were incorporated inside the lipid vesicles.

Clinical Trials Register

The lipid labeling provides a more stable association of the radioactive tracer and the lipid vesicles, while the use of water-soluble radiotracers provides a wider selection of compounds. Early attempts at selective tumor imaging using radiolabeled liposomes were unsuccessful.

The use of monoclonal antibodies attached to liposomes offers new hopes. Several strategies have been proposed in this respect and several others can be envisioned. The use of liposomes permits the use of several administration routes for imaging agents. Of particular interest is the subcutaneous administration for lymph node visualization. Liposomes offer clear advantages over most radiocontrast agents for prolonged hepatosplenic contrast enhancement.

This is particularly relevant in the diagnostic evaluation of the abdomen with computed tomography. Important research efforts are being conducted in this area. Two different approaches have been advanced: Nuclear magnetic resonance imaging can also benefit from contrast agents.

Statistics

Several centers are investigating this exciting field using liposomes loaded with paramagnetic elements. Pegialda of ovalbumin into liposomes –factors affecting entrapment efficiency, liposome size, and zeta potential.

Various amounts of Ovalbumin OVA were encapsulated into positively and negatively charged multilamellar liposomeswith the aim to investigate the entrapment efficiency in different buffers and to study their effects on the liposome size and zeta potential. Also, liposome size was approximately nm for all anionic liposomes incorporating OVA.

The entrapment efficiency of OVA in cationic liposomes was highly dependent on ionic strength. The size of cationic liposomes was approximately nm in PBS, regardless of protein content, but increased with the amount of the incorporated protein in PB. Aggregation of cationic liposomes in PB was observed when the mass of the protein was 2. The zeta potential of anionic liposomes was negative and of cationic li;osomal positive in the whole range of protein mass tested.